THE SMART TRICK OF PKRRATING THAT NO ONE IS DISCUSSING

) mechanism16,thirty–34 [for the contrary perspective see35]. The BTB dimer orients the Lively websites away from the dimer interface within a configuration that cannot mediate this response. Here, we report structures of wild-sort, unphosphorylated PKR kinase. The kinase domains interact by means of the BTB interface and undertake an Energetic c